Azines and Azoloazines, Part 1: Reactions of Triazolo[3,4-a]phthalazine and Its Derivatives with Carbanions

Autor:	I. Okulicz-Kozaryn, Przemysław Mikołajczak, Marek K. Bernard, Wiktoria Zinczenko
Rok vydání:	2014
Předmět:	Hydrogen Stereochemistry Vicarious nucleophilic substitution Organic Chemistry chemistry.chemical_element Ring (chemistry) Medicinal chemistry Pyridazine chemistry.chemical_compound chemistry Nitro Phthalazine Bond cleavage Carbanion
Zdroj:	Journal of Heterocyclic Chemistry. 51:1582-1590
ISSN:	0022-152X
DOI:	10.1002/jhet.1019
Popis:	Triazolo[3,4-a]phthalazine as well as their chloro and nitro derivatives were subjected to the reactions with the carbanions typical for the vicarious nucleophilic substitution (VNS) of hydrogen. The reactions were strongly dependent on the substituents present on the triazolo[3,4-a]phthalazine ring and resulted not only in the substitution of hydrogen but also in exchange of chlorine atom and pyridazine ring scission; the latter process dominated for the unsubstituted triazolophthalazine. Two of the products showed promising stimulating activity towards the central nervous system with no significant toxic effects.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::499f894ba1fdd87a3d12ad044ccdcb20 https://doi.org/10.1002/jhet.1019 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.