The effect of nitrous oxide on intra-ocular pressure in healthy adults*
| Autor: | Rongwei Fu, Kirk Lalwani, Beth Edmunds, E. B. Fox, L. D. Kelly |
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| Rok vydání: | 2012 |
| Předmět: |
inorganic chemicals
Linear mixed effect model education.field_of_study Inhalation business.industry Significant difference Population chemistry.chemical_element Nitrous oxide Oxygen eye diseases chemistry.chemical_compound Anesthesiology and Pain Medicine Intra ocular pressure chemistry Anesthesia Breathing Medicine sense organs education business |
| Zdroj: | Anaesthesia. 67:256-260 |
| ISSN: | 0003-2409 |
| DOI: | 10.1111/j.1365-2044.2011.06989.x |
| Popis: | Summary Many anaesthetic agents affect intra-ocular pressure, yet little is known about nitrous oxide and intra-ocular pressure. This study assessed the effect of nitrous oxide on intra-ocular pressure in 20 healthy adult volunteers. The intra-ocular pressure was measured at baseline, while breathing a 70:30 mix of nitrous oxide and oxygen for 12 min, and then while breathing room air for 15 min. A linear mixed effects model was used to assess change in intra-ocular pressure over time. There was no significant difference in intra-ocular pressure between baseline and during or after nitrous oxide inhalation. Several differences in intra-ocular pressure were noted between internal time-points: pressure increased by 2.4 mmHg between 3 and 6 min of breathing nitrous oxide (p = 0.01); it increased by 1.4 mmHg between 3 and 9 min of breathing nitrous oxide (p = 0.046); and it decreased by 2.2 mmHg between 6 min of breathing nitrous oxide and 15 min of breathing room air (p = 0.035). This study indicates that nitrous oxide inhalation does not significantly change intra-ocular pressure from baseline values in a population of healthy adults. |
| Databáze: | OpenAIRE |
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