Kinetic study on the effects of acidic polysaccharides on the interaction of fibrinogen and thrombin
| Autor: | Hiroko Sato, Eiji Nakanishi, Akio Nakajima |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
chemistry.chemical_classification
Chromatography Polymers and Plastics biology Chemistry Induction period Inorganic chemistry General Chemistry Heparin Polymer Condensed Matter Physics Fibrinogen Polysaccharide Fibrin chemistry.chemical_compound Thrombin Materials Chemistry biology.protein medicine Sulfate medicine.drug |
| Zdroj: | Polymer Bulletin. 3:655-664 |
| ISSN: | 1436-2449 0170-0839 |
| Popis: | Retardation effect of acidic polysaccharides on the interactions of fibrinogen with thrombin was kinetically investigated by measuring the turbidity as a measure of the concentration of fibrin polymer formed in the system. To this aim, the fibrinogenfibrin conversion curve was analyzed kinetically based on the elementary reactions, and the slope and the induction period of the conversion curve were expressed as functions of the concentrations of fibrinogen, thrombin, and polysaccharide. The strong retardation effect of dextran sulfate and heparin was quantitatively interpreted. Seven kinds of polysaccharides were examined. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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