High-performance liquid chromatography of quinidine in plasma, with use of a microparticulate silica column

Autor:	M A Peat, T A Jennison
Rok vydání:	1978
Předmět:	Quinidine Chromatography Correlation coefficient Biochemistry (medical) Clinical Biochemistry Extraction (chemistry) Silica column Ether Plasma High-performance liquid chromatography chemistry.chemical_compound chemistry Standard addition medicine medicine.drug
Zdroj:	Clinical Chemistry. 24:2166-2168
ISSN:	1530-8561 0009-9147
DOI:	10.1093/clinchem/24.12.2166
Popis:	We describe a routine method for determining plasma concentrations of quinidine by liquid chromatography. The procedure requires 1.0 ml of plasma (or serum) and involves internal standard addition, extraction with ether, and separation on a column of microparticulate silica. Day-to-day CV (15 days) was less than 5% and no deterioration in column performance has been observed during 12 months. Comparison with a fluorometric procedure gave a correlation coefficient of 0.995.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::499463171ae0bd8304ea992e5d71ef00 https://doi.org/10.1093/clinchem/24.12.2166 Zobrazit plný text záznamu