Transient neonatal myasthenia gravis following maternal myasthenia gravis presenting in pregnancy after treatment with Alemtuzumab

Autor: Ruppa Mohanram Geethanath, Lauren Dhugga, Chike Onwuneme
Rok vydání: 2020
Předmět:
Zdroj: Case Reports in Perinatal Medicine. 9
ISSN: 2192-8959
2192-8932
DOI: 10.1515/crpm-2020-0065
Popis: Ojectives Transient neonatal Myasthenia gravis is a postsynaptic neuromuscular junction disorder seen in 10–21% of infants born to mothers with myasthenia gravis. Alemtuzumab is an anti-CD52 monoclonal antibody used in the treatment of multiple sclerosis. The possibility of developing Myasthenia gravis in a pregnant mother treated with Alemtuzumab is rare. Case presentation We report a case of transient neonatal myasthenia gravis following treatment with Alemtuzumab for multiple sclerosis in the mother. Conclusions Therapy with Alemtuzumab increases the risk of secondary autoimmune diseases including Myasthenia gravis.
Databáze: OpenAIRE