Dendritic cell-expressed CD103 is required for inhibition of mucosal Th2 cell responses (90.3)
| Autor: | Sarah Mullaly, Steven Maltby, Kyle Burrows, Kelly McNagny, Colby Zaph |
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| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 184:90.3-90.3 |
| ISSN: | 1550-6606 0022-1767 |
| Popis: | Dysregulated mucosal CD4 Th2 cell responses are a feature of several inflammatory diseases including asthma, allergies and some forms of inflammatory bowel disease. The integrin CD103 is expressed primarily on a subset of dendritic cells (DCs) that promote regulatory T cell development and intestinal immune homeostasis. However, the role of CD103 in Th2-dependent immunity has not been tested. Using the helminth parasite Trichuris muris, we identify a critical role for CD103 in specifically limiting Th2 responses in vivo. We find that following infection with Trichuris, CD103-deficient (CD103-/-) mice develop an enhanced Th2 response that is associated with decreased levels of IL-10. While in vitro CD4 T cell differentiation was unaffected by CD103 deficiency, bone marrow-derived CD103-/- DCs induce heightened T cell proliferation and increased IL-13 production under Th2 promoting conditions. The inhibitory role of CD103 appears to be specific for Th2 responses, as CD103-/- mice are protected from disease development in a model of chemically-induced colitis. Taken together, these results suggest that CD103 expression on DCs is critically required to specifically regulate Th2 immune responses in vivo. |
| Databáze: | OpenAIRE |
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