Colorectal and bladder prokinetic activity of [Lys5, MeLeu9, Nle10]-NKA(4–10) after intranasal or sublingual delivery in dogs
| Autor: | Nadia M.J. Rupniak, Mary A. Katofiasc, Jungeun Bae, Karl B. Thor, Lesley Marson |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Canadian Journal of Physiology and Pharmacology. 101:171-179 |
| ISSN: | 1205-7541 0008-4212 |
| DOI: | 10.1139/cjpp-2022-0498 |
| Popis: | The feasibility of eliciting defecation and urination after intranasal (IN) or sublingual (SL) delivery of a small peptide NK2 receptor agonist, [Lys5, MeLeu9, Nle10]-NKA(4–10), was examined using prototype formulations in dogs. In anesthetized animals, administration of 100 or 300 µg/kg IN or 2.0–6.7 mg/kg SL increased colorectal peak pressure and area under the curve. Peak bladder pressure was also increased at the same doses, and this was accompanied by highly efficient voiding at normal physiological bladder pressure. The onset of these effects was rapid (≤2.5 min), and the primary contractions lasted ∼25 min, returning to baseline in |
| Databáze: | OpenAIRE |
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