| Autor: |
Nkemngo Francis Nongley, Jean Leon Mugenzi Mbugulize, Ebai Terence, Abdoulaye Niang, Murielle Wondji, Micareme Tchoupo, Daniel Nguiffo Nguete, Williams Tchapga, Helen Irving, Stephen M. Ghogomu, Cyrille Ndo, COMAL Consortium, Steffen Borrmann, Charles S. Wondji |
| Rok vydání: |
2020 |
| Předmět: |
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| DOI: |
10.21203/rs.2.23277/v1 |
| Popis: |
Background Reducing the burden of malaria requires better understanding of vector populations particularly in forested regions where the incidence remains elevated. Here, we characterized malaria vectors in a locality near the international airport of Yaoundé, the capital city of Cameroon, including species composition, abundance, Plasmodium infection rate; insecticide resistance profiles and underlying resistance mechanisms. Methods Blood-fed adult mosquitoes resting indoors were aspirated from houses in April 2019 at Elende, a village located 2km from the Yaoundé-Nsimalen airport. Female mosquitoes were forced to lay eggs to generate F 1 adult progeny. WHO bioassays were performed to assess resistance profile to insecticides. The threshold of insecticide susceptibility was fixed above 98% mortality rate and mortality rates below 90% were considered indicative of confirmed insecticide resistance according to the WHO test procedures for insecticide resistance monitoring. Furthermore, the molecular basis of resistance and Plasmodium infection rates were investigated.Results Anopheles funestus s.s. was most abundant species in Elende (85%) followed by Anopheles gambiae s.s. (15%) with both having a similar sporozoite infection rate. Both species exhibited high levels of resistance to pyrethroids (Plasmodium infection rate highlights the challenges that public health vector control programs encounter in sustaining the regular effectiveness of contemporary insecticide-based control interventions in forested areas. More particularly, the resistance observed against the carbamates and possible resistance against the organophosphates constitutes a major concern for IRS. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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