Determination of (fluoro)quinolone antibiotic residues in pig kidney using liquid chromatography–tandem mass spectrometry

Autor:	M. Chedin, Guy Bordin, B. Toussaint, Adela Rosa Rodríguez
Rok vydání:	2005
Předmět:	Chromatography Chemistry Organic Chemistry General Medicine Reversed-phase chromatography Repeatability Mass spectrometry Biochemistry High-performance liquid chromatography Analytical Chemistry Liquid chromatography–mass spectrometry Sample preparation Solid phase extraction Antibacterial agent
Zdroj:	Journal of Chromatography A. 1088:32-39
ISSN:	0021-9673
DOI:	10.1016/j.chroma.2005.02.057
Popis:	A new LC–MS/MS method has been developed for the multiresidue determination of 11 (fluoro)quinolone antibiotics (FQs), including acidic and amphoteric species, around their maximum residue level (MRL) in pig kidney. The procedure involves a common sample preparation by solid-phase extraction on disposable extraction cartridges followed by a fast reversed-phase liquid chromatography–tandem mass spectrometry analysis. The method was validated according to the Commission Decision 2002/657/CE. The accuracy of the method was satisfactory with recoveries included in the interval 80–100%. The precision results showed mean repeatability and reproducibility coefficients of 7.4% and 11.8%, respectively. Limits of quantification much lower than the MRLs could be obtained.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::498096d7c7ac8cd8cdd2cdaa92f47591 https://doi.org/10.1016/j.chroma.2005.02.057 Zobrazit plný text záznamu Full Text from ScienceDirect