Epidemiological, Clinical and Evolutive Profile of Autosomal Dominant Polycystic Kidney Disease (ADPKD) in Togo

Autor: Djibril Mohaman Awalou, Dolaama Badomta, Tona Komlan Georges, Attisso Eugene, Amekoudi Eyram Yoan, Hadabia D’daah, Kodjo Kossi, Djagadou Kodjo Agbeko, Sabi Kossi Akomola, Tsevi Yawovi Mawufemo, Nemi Komi Dzidzonu
Rok vydání: 2018
Předmět:
Zdroj: Open Journal of Nephrology. :117-123
ISSN: 2164-2869
2164-2842
DOI: 10.4236/ojneph.2018.84013
Popis: Objective: To describe the epidemiological, clinical and evolutionary profile of ADPKD in Togo. Methods: A retrospective descriptive transversal study over a period of 8 years (2011-2018) which focused on the analysis of patients’ records diagnosed with ADPKD. The diagnosis of ADPKD was retained on the basis of the ultrasound criteria of PEI. Results: During the study period, 27 patients had polycystic kidney disease with a prevalence of 0.87%. The average age was 51.6 ± 16.4 years. There were 10 men (37%) and 17 women (63%), a sex ratio (M/F) of 0.58. The concept of family cystic kidney disease was found in 6 (22.2%) patients. The clinical presentations were dominated by arterial high blood pressure, abdominal pain and abdominal mass respectively in 77%, 63% and 63% of cases. Five patients (18.5%) had a glomerular filtration rate (GFR) greater than 90 ml/min, 17 (62.9%) had a GFR < 60 ml/min. All patients (100%) had multiple renal cysts, 16 patients (59.3%) had dedifferentiated kidneys. Six patients (22.2%) had liver cysts, one patient (3.7%) had lithiasis. Genetic was not achieved because of the poor technical platform and the high cost of these tests. Conclusion: ADPKD is common in our department. It appears to be associated with a high rate of chronic renal failure.
Databáze: OpenAIRE
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