| Autor: |
Madeleine H. Moore, John M. Vernon, Keith M. Morgan, Patrick D. Bailey, Ian D. Collier, David I. Smith, S. P. Hollinshead |
| Rok vydání: |
1994 |
| Předmět: |
|
| Zdroj: |
J. Chem. Soc., Chem. Commun.. :1559-1560 |
| ISSN: |
0022-4936 |
| DOI: |
10.1039/c39940001559 |
| Popis: |
When the homologated nitrile 11 derived from L-tryptophan undergoes a modified Pictet–Spengler reaction with methyl propynoate, the resulting cis-tetrahydro-β-carboline 12a is ideally functionalised for cyclisation to the bridged ketonitrile 14; simple functional group modification via the nitrile 15(structure confirmed by X-ray crystallography) allow convergence with the tetracyclic α,β-unsaturated aldehyde 10, which is an advanced intermediate for the synthesis of a range of bridged indole alkaloids. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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