Drugs and the frog retina
| Autor: | Milena Kemali, N. Milici, Dargut Kemali |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Pharmacology
medicine.medical_specialty Retina genetic structures Dopaminergic Retinal Biology Dopamine agonist Apomorphine Melanin Cellular and Molecular Neuroscience chemistry.chemical_compound medicine.anatomical_structure Endocrinology chemistry Dopamine Internal medicine Biophysics medicine GRENOUILLE sense organs medicine.drug |
| Zdroj: | Neuropharmacology. 23:381-385 |
| ISSN: | 0028-3908 |
| DOI: | 10.1016/0028-3908(84)90203-x |
| Popis: | This is a study, using the light and electron microscope, of the action of a dopamine agonist (apomorphine) and of a dopamine antagonist (haloperidol) on the retinal pigment screening (PS) of light- and dark-adapted frogs. Pigment screening is a phenomenon which consists of the migration of melanin granules into processes of the pigment epithelium that extend between photoreceptors, in response to changes in the conditions of illumination. In the light the pigment migrates vitreally , in the dark it aggregates sclerally . A single intravenous injection of apomorphine (0.15 mg/kg) and of haloperidol (1 mg/kg) did not induce substantial modifications in the pattern of pigment screening which was similar to that of controls both in light- and dark-adapted frogs. This suggests that dopamine is probably not directly involved in the phenomenon of pigment screening in the retina of the frog. |
| Databáze: | OpenAIRE |
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