Palladium-Catalyzed Intramolecular Cross-Coupling of Unactivated C(sp3)–H and C(sp2)–H Bonds

Autor:	Yanghui Zhang, Xueliang Sun, Zhengyang Zhang, Weixin Qi, Zechen Wu, Zhuo Wu
Rok vydání:	2021
Předmět:	chemistry.chemical_classification Aryl Organic Chemistry chemistry.chemical_element Cleavage (embryo) Biochemistry Medicinal chemistry Catalysis Coupling (electronics) chemistry.chemical_compound chemistry Intramolecular force Physical and Theoretical Chemistry Alkyl Palladium
Zdroj:	Organic Letters. 23:7161-7165
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.1c02567
Popis:	Direct C-H/C-H coupling represents an appealing method for the construction of C-C bonds, and the cross-coupling of unactivated C(sp3)-H and C(sp2)-H bonds is challenging and remains to be investigated. We have developed the Pd-catalyzed intramolecular coupling of inert C(sp3)-H and C(sp2)-H bonds. The reaction proceeded by o-methyl oxime-directed aryl C(sp2)-H activation and subsequent alkyl C(sp3)-H cleavage, generating C(sp2),C(sp3)-palladacycles as the key intermediates. Dihydrobenzofurans and indanes were formed as the final products.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::496ffab7947a00cc0c52b3e551f315a5 https://doi.org/10.1021/acs.orglett.1c02567 Zobrazit plný text záznamu