RESOLUTION OF FLUORINATED AMINOMETHANPHOSPHONIC ACIDS CATALYSED BY PENICILLIN G ACYLASE - III
| Autor: | V. Giraud, Gerhard Hägele, Ulrike Gruss, A. Haas, C. Rabiller, D. Vaubaillon |
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| Rok vydání: | 1997 |
| Předmět: | |
| Zdroj: | Phosphorus, Sulfur, and Silicon and the Related Elements. 126:177-183 |
| ISSN: | 1563-5325 1042-6507 |
| DOI: | 10.1080/10426509708043557 |
| Popis: | In this work. we have used Penicillin G acylase (EC 3.5.1.11) from E. coli to resolve kinetically four fluorinated aminomethanphosphonic acids : 1, 1: 1-trifluorornethyl-. 2: 1-p-fluorophenyl-, 3: 1-m-fluorophenyl-, 4: l-p-trifluoromethylphenyl-l-aminomethanphosphonic acids. This enzyme catalyses enantioselectively the hydrolysis of the N-phenylacetylated derivatives of 1–4. The enantiomeric excesses determined via 31P NMR spectra of the diastereomeric Pd(II) complexes of 1–4 were high for each compound studied. Dans ce travail, on a utilise la Penicilline G acylase (EC 3.5.1.11) de E. coli pour effectuer la resolution cinetique de quatre acides aminomethanphosphoniques fluores: acides 1, 1-trifluorornethyl-. 2: 1-p-fluorophenyl-, 3: l-m-fluorophenyl-, 4: 1-p-trifluoromethylphenyl—1-aminomethanphosphoniques. Cette enzyme catalyse enantioselectivement l'hydrolyse des derives N-phenylacieyles des composes 1–4.. Les exces enantiomeriques calcules gr[acaron]e aux spectres RMN du 31P des coniplexes di... |
| Databáze: | OpenAIRE |
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