Calcineurin inhibitor withdrawal and conversion to mycophenolate mofetil and steroids in cardiac transplant recipients with chronic renal failure: a word of caution

Autor:	Peter Überfuhr, Ingo Kaczmarek, Bruno Meiser, Helmut Gulbins, Jan Groetzner, Sabine Daebritz, Johannes Schirmer, Bruno Reichart
Rok vydání:	2008
Předmět:	Transplantation medicine.medical_specialty business.industry medicine.medical_treatment Urology Renal function Immunosuppression medicine.disease Tacrolimus Mycophenolic acid Surgery Calcineurin Prednisone medicine business Kidney disease medicine.drug
Zdroj:	Clinical Transplantation. 22:587-593
ISSN:	0902-0063
DOI:	10.1111/j.1399-0012.2008.00828.x
Popis:	Background: Chronic renal failure (CRF) is a common complication of calcineurin inhibitor (CNI)-based immunosuppression following cardiac transplantation (HTx). The aim of this prospective study was to evaluate the impact of an immunosuppressive conversion from CNIs to mycophenolate mofetil (MMF) and steroids in cardiac transplant recipients with CRF on renal and cardiac graft function. Methods: Since 1999, 12 HTx recipients (10 men; 58 ± 3.6 yr of age; 8.7 ± 4.2 yr after HTx) with CNI-based immunosuppression and a calculated creatinine clearance (CreaCl)
Databáze:	OpenAIRE
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