A study on the anticonvulsant activity of Withania somnifera (Dunal) in albino rats
| Autor: | Ajay D Shanbhag, Basavanna Pl, Nagesh Hn, Santhosh Kumar Raju |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0106 biological sciences
animal structures biology Anabolism Physiology business.industry 010604 marine biology & hydrobiology medicine.medical_treatment Hindlimb 010501 environmental sciences Withania somnifera Pharmacology biology.organism_classification Body weight 01 natural sciences Tonic (physiology) Clonus Anticonvulsant medicine General Pharmacology Toxicology and Pharmaceutics medicine.symptom Pentylenetetrazol business 0105 earth and related environmental sciences medicine.drug |
| Zdroj: | National Journal of Physiology, Pharmacy and Pharmacology. 7:17 |
| ISSN: | 2320-4672 |
| DOI: | 10.5455/njppp.2016.6.0615112072016 |
| Popis: | Background: The present study is an investigation of antiepileptic activity of Withania somnifera (Ashwagandha) is a well-known plant which is being used in tuberculosis, emaciation, sterility, and it has immunomodulatory, anabolic, anti-inflammatory, and antianxiety activities. Aims and Objectives: To find the efficacy of the alcoholic extract of W. somnifera (Dunal) in preventing experimentally-induced seizures. Materials and Methods: The alcoholic extract of W. somnifera was subjected to pilot study and then screened for anticonvulsant activity on maximal electroshock (MES) and pentylenetetrazole (PTZ)-induced seizures models in albino Wistar rats. Animals were treated with W. somnifera at doses of 100 mg/kg, 200 mg/kg, and 300 mg/kg body weight and compared the results with control and standard. Results: Study results showed that W. somnifera extract at the dose of 300 mg/kg body weight when compared to control group highly significant (P < 0.01) reduction of hindlimb tonic extension and postictal depression in MES. PTZ-induced seizures showed significantly reduced mean duration of hindlimb tonic flexion, hindlimb tonic extension, clonus, and stupor and there was no postictal depression. Conclusions: The alcoholic extract of W. somnifera (Dunal) has shown a significant anticonvulsant effect at the dose of 300 mg/kg body weight, both in MES method and PTZ method and has given higher protection rate against pentylenetetrazol seizure than MES. |
| Databáze: | OpenAIRE |
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