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The NK cell is a major player in anti-cancer immunity, and hyperthermia augments host immunity against cancer. In cancer patients, NK cell activity is often suppressed. Therefore, when treating cancer patients with hyperthermia, it is desirable to restore the NK cell activity by co-administering a large number of highly activated NK cells that are prepared using a sophisticated cell culture strategy. This chapter describes ex vivo-expanded NK cells used in immunotherapy, the effects of hyperthermia on NK activity, and clinical applications of the combinatory therapy with hyperthermia and NK cells. |
