Abstract 559: Systemic Oxidative Stress is Associated with Myocardial Perfusion in Whites but not in Blacks: The Bogalusa Heart Study
| Autor: | Camilo Fernández Alonso, Shengxu Li, Roberto Blandon, Sathanur R Srinivasan, Wei Chen, Gerald S Berenson |
|---|---|
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Arteriosclerosis, Thrombosis, and Vascular Biology. 33 |
| ISSN: | 1524-4636 1079-5642 |
| DOI: | 10.1161/atvb.33.suppl_1.a559 |
| Popis: | Central and peripheral vascular damage by oxidative stress-mediated mechanisms has been described in male and female patients with inflammatory pathologies. However, information is scant on the association between oxidative stress and myocardial perfusion in biracial (black-white) asymptomatic young adults. We assessed the hypothesis that the association between oxidative stress and myocardial perfusion differs among biracial (black-white) asymptomatic young adults. As a part of the Bogalusa Heart Study, systemic oxidative stress (in terms of urinary creatinine-indexed levels of 8-epi-PGF2alfa -isoprostane-) and non-invasive myocardial perfusion (in terms or Subendocardial Viability Ratio -SEVR) were assessed in 605 asymptomatic individuals aged 29-51 years (mean 43.4; 68.7% white and 54.4% female), along with evaluation of traditional cardiovascular risk factors. The race-specific association of urinary creatinine -indexed 8-epi-PGF2alfa with SEVR was tested through multivariable- adjusted linear regression analyses. SEVR levels were significantly higher in white and male participants (p In conclusion, the described observations help support the hypothesis that the impact of oxidative stress on myocardial perfusion (coronary microcirculation) is different among race (black-white) groups. Further, this may aid to emphasize and enhance race-specific risk factor screening and disease evaluation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|