Mobilization of intracellular Ca2+ induced by ADP and thrombin in platelets from diabetic patients with vascular complications
| Autor: | Tomilova En, Balashova Ts, Rud'ko Ia, Kubatiev Aa |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
Mobilization business.industry Insulin medicine.medical_treatment General Medicine Baseline level medicine.disease General Biochemistry Genetics and Molecular Biology Thrombin Endocrinology Diabetes mellitus Internal medicine medicine Platelet In patient business Intracellular medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 121:104-107 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf02445720 |
| Popis: | It is shown that the baseline level of cytoplasmic Ca2+ in platelets from diabetic patients is nearly 1.5 times as high as in healthy donors. The thrombin-induced increase of intracellular Ca2+ in patients with angiopathies is reliably lower than in the control, while in patients without angiopathies it is higher than that in donor platelets. The evevation of cytoplasmic Ca2+ induced by ADP is greater in both groups of patients. No Changes are found in the baseline level of intracellular Ca2+ or in the ADP-induced concentration of Ca2+ in platelets from diabetic patients during a 12-week course of insulin therapy. The intracellular Ca2+ does not rise after 2 weeks of insulin treatment in platelets from diabetic patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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