Monitoring ring-closing metathesis: Limitations on the utility of 1H NMR analysis

Autor:	Sebastien Monfette, Glenn A. Facey, Joao A. Duarte Silva, Eduardo N. dos Santos, Maria Helena Araujo, Deryn E. Fogg, Angela K. Crane
Rok vydání:	2010
Předmět:	Inorganic Chemistry chemistry.chemical_compound Ring-closing metathesis Diene Olefin metathesis Computational chemistry Chemistry Stereochemistry Materials Chemistry Proton NMR Physical and Theoretical Chemistry Metathesis
Zdroj:	Inorganica Chimica Acta. 363:481-486
ISSN:	0020-1693
DOI:	10.1016/j.ica.2009.09.030
Popis:	The utility and limitations of 1H NMR methods for monitoring the progress of ring-closing metathesis (RCM) reactions are examined. 1H NMR analysis of RCM reactions that yield macrocyclic and medium-ring products can be more problematic than is generally recognized. Interpretation is complicated by the formation of oligomers with an NMR signature identical or closely similar to that of the diene precursor, the RCM target, or a composite of the two. DOSY-NMR can aid in resolving ambiguities in signal assignment, but reliable quantitation requires ancillary methods.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::49420aa23770c2757478fbded80d523e https://doi.org/10.1016/j.ica.2009.09.030 Zobrazit plný text záznamu Full Text from ScienceDirect