Synthesis and Antimicrobial Properties of Ammonium Salts Containing a Substituted Butyn-2-yl Group
| Autor: | R. V. Paronikyan, A. Kh. Gyul’nazaryan, A. V. Babakhanyan, M. O. Manukyan, N. S. Minasyan, G. M. Stepanyan, K. S. Barsegyan |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pharmacology chemistry.chemical_classification 010405 organic chemistry Radical Pharmacology toxicology Antimicrobial 01 natural sciences 0104 chemical sciences 03 medical and health sciences Acetic acid chemistry.chemical_compound 030104 developmental biology chemistry Group (periodic table) Drug Discovery polycyclic compounds Organic chemistry Ammonium Antibacterial activity Alkyl |
| Zdroj: | Pharmaceutical Chemistry Journal. 51:764-768 |
| ISSN: | 1573-9031 0091-150X |
| DOI: | 10.1007/s11094-017-1689-x |
| Popis: | Interaction of 1-dimethylamino-4-diethylaminobutyn-2, 1-dimethylamino-4-piperidinobutyn-2, and 1-dimethylamino-4-morpholinobutyn-2 with the corresponding alkyl esters of monobromo(chloro)acetic acid was used to synthesize novel monoammonium salts. Studies of the antimicrobial activity of the resulting compounds showed that salts containing hydrophobic alkoxycarbonylmethyl radicals had marked antibacterial activity against Gram-positive and Gram-negative microorganisms. |
| Databáze: | OpenAIRE |
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