Effects of Macrophage Colony-Stimulating Factor on Antifungal Activity of Neonatal Monocytes against Candida albicans
| Autor: | Vasiliki Drossou, Emmanuel Roilides, Christos Farmakis, Elias Gioulekas, John Tsiouris, George Kremenopoulos, Michael Goutzioulis |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Macrophage colony-stimulating factor
Chemotherapy biology medicine.medical_treatment Monocyte Biological activity Fungi imperfecti biology.organism_classification Microbiology law.invention medicine.anatomical_structure Cytokine law Pediatrics Perinatology and Child Health Immunology Recombinant DNA medicine Candida albicans Developmental Biology |
| Zdroj: | Neonatology. 80:251-256 |
| ISSN: | 1661-7819 1661-7800 |
| DOI: | 10.1159/000047152 |
| Popis: | The effects of recombinant macrophage-colony stimulating factor (M-CSF) on antifungal activities of monocytes (MNC) from healthy neonates and adults against Candida albicans were compared. Pretreatment of adult and neonatal MNC with 15 ng/ml of M-CSF for 4 days significantly increased superoxide anion (O2–) production in response to phorbol myristate acetate. While M-CSF-treated MNC from adults produced significantly higher O2– in response to Candida blastoconidia, M-CSF-treated neonatal MNC did not show a similar response. Further, M-CSF significantly enhanced phagocytosis of C. albicans by adult MNC but not by neonatal MNC. While M-CSF enhances antifungal activities of adult MNC against C. albicans, it does not appear to affect anticandidal function of neonatal MNC. |
| Databáze: | OpenAIRE |
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