Nucleotide sequence analysis and comparison of the structural genes for Shiga-like toxin I and Shiga-like toxin II encoded by bacteriophages fromEscherichia coli933
| Autor: | Alison D. O'Brien, Randall K. Holmes, Roger Neill, John W. Newland, Matthew P. Jackson |
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| Rok vydání: | 1987 |
| Předmět: |
Genetics
genetic structures Operon Structural gene Protein primary structure Nucleic acid sequence Biology medicine.disease_cause biology.organism_classification Microbiology Bacteriophage chemistry.chemical_compound Shiga-like toxin chemistry medicine Molecular Biology Escherichia coli Peptide sequence |
| Zdroj: | FEMS Microbiology Letters. 44:109-114 |
| ISSN: | 1574-6968 0378-1097 |
| DOI: | 10.1111/j.1574-6968.1987.tb02252.x |
| Popis: | The nucleotide sequence of the Shiga-like toxin type II (SLT-II) structural genes cloned from bacteriophage 933W of the enterohemorrhagic Escherichia coli O157:H7 strain 933 was determined. This sequence was compared with the published sequence for the structural genes of the antigenically distinct Shiga-like toxin type I (SLT-I) encoded by bacteriophage 933J. The SLT-I and SLT-II structural genes shared 58% overall nucleotide and 56% amino acid sequence homologies. The A and B subunits of SLT-I and SLT-II were nearly identical in size and had similar secondary structures and hydropathy plots. The regulation proposed for the SLT-II operon is similar to that previously proposed for SLT-I. |
| Databáze: | OpenAIRE |
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