Spectroscopic Studies on the Molecular Complex of the Drug Atenolol with Iodine

Autor: M. Pandeeswaran, K. P. Elango
Rok vydání: 2009
Předmět:
Zdroj: Journal of Solution Chemistry. 38:1558-1572
ISSN: 1572-8927
0095-9782
DOI: 10.1007/s10953-009-9467-3
Popis: Spectroscopic and spectrofluorimetric studies were made of the interaction between the drug atenolol and iodine. The interaction was found to proceed through the initial formation of a charge transfer (CT) complex as an intermediate species. The product of this interaction has been isolated and characterized using UV-Vis, FT-IR and Raman spectroscopic techniques. Formation of the triodide $\mathrm{I}_{3}^{-}$ species was confirmed by its electronic and Raman spectra. Peaks appeared in Raman spectrum of the isolated product at 153, 102 and 85 cm−1 that are assigned to ν as(I-I), ν s(I-I) and $\delta(\mathrm{I}_{3}^{-})$ respectively, which confirmed the presence of the $\mathrm{I}_{3}^{-}$ ion. The stoichiometry of the complex was found to be 1:2. The rate of their reaction has been measured as a function of time and solvent. Pseudo-first-order rate constants for the reaction were measured at various temperatures and the thermodynamic activation parameters (ΔG #,ΔS # and ΔH #) were computed. Preliminary fluorescence quenching studies indicated that the interaction between atenolol and iodine is spontaneous and proceeds through a CT complex, and the quenching of fluorescence of atenolol by iodine increases as the extent of such complexation increases
Databáze: OpenAIRE
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