Synthesis of methyl-substituted lariat ethers containing a 13-crown-4 ring

Autor:	Mitsuo Okahara, Masayuki Yonetani, Ryuhei Wakita, Yohji Nakatsuji
Rok vydání:	1990
Předmět:	chemistry.chemical_compound chemistry Organic Chemistry Alkoxide Moiety Organic chemistry Ether Ring (chemistry) Medicinal chemistry
Zdroj:	Journal of Heterocyclic Chemistry. 27:1337-1339
ISSN:	1943-5193 0022-152X
DOI:	10.1002/jhet.5570270529
Popis:	Convenient synthetic procedures for preparing two kinds of methyl-substituted lariat ethers containing a 13-crown-4 ring, are described.Some of these compounds were obtained from the reaction of 2-bromomethyl-2-methyl-13-crown-4 (I) with the appropriate alkoxide. Compound I was prepared without the need for prior protection of the bromomethyl group. For the synthesis of other title compounds , which possess an electron-donating group on the central carbon of the trimethyl moiety of the 13-crown-4 ring, the substituents were introduced before cyclization.
Databáze:	OpenAIRE
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