Electrochemical behaviour and microdetermination of a new cytostatic agent: The aclacinomycin

Autor: Gaston Patriarche, M. Chateau-Gosselin, J. C. Vire
Rok vydání: 1983
Předmět:
Zdroj: Mikrochimica Acta. 81:457-465
ISSN: 1436-5073
0026-3672
DOI: 10.1007/bf01196726
Popis: Aclacinomycin or aclarubicin (D. C. I.), a new cytostatic agent related to the anthracyclin group, has been investigated using d. c., a. c. and d. p. polarographic techniques and cyclic voltammetry. The reduction of the quinonic structure of this compound gives rise to a well defined two-electron wave between -0.22 V and-0.80 V vs. S. C. E. for a pH range from 1.0 to 13.0. The reversibility of this electrochemical process is lower than that of a simple quinonic derivative and is pH independent. Some adsorption phenomena may interfere. The reduction product is adsorbed at the mercury electrode and may partially inhibit the voltamperometric response. At a carbon paste electrode, aclacinomycin shows an anodic wave which may be assigned to the oxidation of one of the phenolic function of the anthraquinonic nucleus. Quantitative determinations of aclacinomycin were carried out in a pH 6 buffered medium. A very good linearity was observed in the 1×10−3 to 1×10−5 M concentration range. The stability of aclacinomycin is significantly better than that of other quinonic derivatives both in alkaline medium and under light effect.
Databáze: OpenAIRE
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