EFFECT OF ALPHA-COBRATOXIN ON THE OXIDATIVE STRESS INDUCED BY A SERUM-FREE MEDIUM IN C6 GLIOMA CELLS

Autor:	Alexey V. Osipov, Yu. N. Utkin, S. B. Kondrashova, V. S. Ulashchyk, T. I. Terpinskaya
Rok vydání:	2018
Předmět:	biology Superoxide General Medicine Glutathione Pharmacology medicine.disease_cause Redox Superoxide dismutase chemistry.chemical_compound Nicotinic agonist chemistry Catalase medicine biology.protein Oxidative stress Acetylcholine receptor
Zdroj:	Proceedings of the National Academy of Sciences of Belarus, Medical series. 15:199-206
ISSN:	2524-2350 1814-6023
DOI:	10.29235/1814-6023-2018-15-2-199-206
Popis:	The model studies on C6 glioma cells showed that the role of nicotinic acetylcholine receptors (nAChR) in the regulation of the redox balance varies under different cultivation conditions. In a serum-free medium, the inhibitor of nAXP alpha-cobratoxin alleviates the oxidative stress that is manifested in an increase in the activity of superoxide dismutase and catalase, the level of reduced glutathione and in a decrease in the concentration of malonic dialdehyde.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::49227fe05d58340d3b8f931fff35ab9a https://doi.org/10.29235/1814-6023-2018-15-2-199-206 Zobrazit plný text záznamu