GW24-e1008 The hypolipidaemic activity of danlou tablet extract in Triton WR-1339 induced hyperlipidaemic rats: A comparison with rosuvastatin
| Autor: | Wu Feng, Wu Zonggui, Ji Ruizhen, Liang Chun, He Zhiqing, Yu Chenghong |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Triglyceride
business.industry Blood lipids Lipid metabolism Traditional Chinese medicine Pharmacology Cholesterol 7 alpha-hydroxylase medicine.disease Triton WR-1339 chemistry.chemical_compound chemistry Hyperlipidemia Medicine Rosuvastatin Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Heart. 99:A90.3-A91 |
| ISSN: | 1468-201X 1355-6037 |
| DOI: | 10.1136/heartjnl-2013-304613.245 |
| Popis: | Objectives We have studied method of Danlou tables’ dynamic effcet on serum cholesterol, triglyceride in experimental acute hyperlipidemia rats. Methods 48 healthy adult male SD rats were randomly divided into 6 groups: blank control group, model control group, rosuvastatin group, low dose of Danlou tablet group, medial dose of Danlou tablet group, high dose of Danlou tablet group, Continuous administrate drug 14 days later, through tail intravenous Trition- WR1339 and high fat diets, building acute hyperlipidemia rat model, and observe dynamic change of blood lipid index within 48 hour after building model, levels of liver lipid and expression of relevant lipid metabolism genes. Results administration of high dose Danlou tablet can significantly inhibit an acute rise in serum TC and TG caused by Trition-WR1339 (P Conclusions Danlou tablet and relevant traditional Chinese medicine can effectively reduce both plasma cholesterol and triglyceride levels, do not cause liver lipid deposition, and its mechanism may be related to increased expression of liver CYP7A1 and reduce ACC synthesis. |
| Databáze: | OpenAIRE |
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