Differential regulation of insulin‐like growth factor binding protein (IGFBP)‐2 mRNA in liver and bone cells by insulin and retinoic acid in vitro
| Autor: | M. Böni-Schnetzler, I. Schläpfer, M. Waldvogel, Ch. Schmid, J. Zapf, J. Schwander, Peter J. Meier, Ernst Rudolf Prof Dr Froesch |
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| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Insulin medicine.medical_treatment Growth factor Biophysics Retinoic acid Osteoblast Cell Biology Biology Biochemistry Insulin-like growth factor-binding protein chemistry.chemical_compound Retinoic acid receptor Endocrinology medicine.anatomical_structure chemistry Structural Biology Internal medicine Insulin-like growth factor 2 Bone cell Genetics medicine biology.protein Molecular Biology hormones hormone substitutes and hormone antagonists |
| Zdroj: | FEBS Letters. 303:205-209 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/0014-5793(92)80520-q |
| Popis: | Isolated cells produce insulin-like growth factors (IGFs) and their binding proteins (IGFBPs). Two distinct cell types were studied with regard to IGFBP-2 expression: (i) rat hepatocytes, which produce IGF I at a high rate and thus regulate its plasma concentration; and (ii) rat osteoblasts, which are targets of IGF I action. IGFBP-2 expression is low in hepatocytes prepared from normal adult rats and high in calvaria cells from newborn rats. Retinoic acid stimulates IGFBP-2 production by liver cells. Insulin suppresses both basal and retinoic acid-induced IGFBP-2 mRNA expression in hepatocytes and has no such effect on osteoblasts. Retinoic acid and insulin regulate IGFBP-2 expression in a tissue-specific manner. |
| Databáze: | OpenAIRE |
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