Effects of Feeding Sialyllactose and Galactosylated N-Acetylneuraminic Acid on Swimming Learning Ability and Brain Lipid Composition in Adult Rats

Autor:	Tadasu Urashima, Kenzo Ohtsuki, Shuichi Yanahira, Yoshihiro Ikeuchi, Michio Fujihara, Fumihiko Sakai
Rok vydání:	2006
Předmět:	medicine.medical_specialty Ganglioside Lipid accumulation Cerebro Sphingolipid chemistry.chemical_compound Endocrinology chemistry Biochemistry Galactose Internal medicine medicine Composition (visual arts) Lactose N-Acetylneuraminic acid
Zdroj:	Journal of Applied Glycoscience. 53:249-254
ISSN:	1880-7291 1344-7882
DOI:	10.5458/jag.53.249
Popis:	The learning behavior of adult rats was studied using a water-filled multiple T-maze apparatus and a Morris swimming-maze after feeding lactose, galactosyllactose (GL), N-acetylneuraminic acid (Neu5Ac), sialyllactose (SL) or galactosylated N-acetylneuraminic acid (GN) and a control diet. The learning behavior tended to improve in the groups fed SL or GN when compared with the other groups. The concentrations of gangliosides and GM3 in brain were significantly higher in the groups fed SL or GN. The data show that the feeding of SL or GN to adult rats raised the brain ganglioside and GM3 contents, which may be related to improvement in the swimming learning behavior.
Databáze:	OpenAIRE
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