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Introduction: Changes in haematological characteristics in patients with COVID-19 are emerging as important features of the disease. We aim to study hematological characteristics and differences in these parameters between severe and non-severe COVID-19 patients. Methods: We included 114 patients admitted to Charles Nicolle hospital in Tunis, from September to December 2020, with positive RT-PCR for SARS-CoV-2. Patient data were extracted from electronic medical records and compared between moderate and severe disease. Results: Severe form was noted in 72% of the patients, with a maximum required oxygen flow of 11±5 liters. Twenty five patients (22%) were transferred to the ICU, and 10.6% died. WBC and neutrophils were higher in severe forms (9650 vs. 8848/mm3, p>0.05; 7993 vs. 6859/mm3, p>0.05 respectively). The lymphocyte count was lower in severe disease (1177 vs. 1302/mm3, p>0.05). D-dimer significantly increased with increasing disease severity (9457 vs. 1542 µg/l, p=0.003). Eosinophile rate was lower in the severe forms (16 vs. 27.6/mm3, p>0.05), similarly for prothrombin ratio (60% vs. 68%, p>0.05). Fibrinogen rate increased with the severity of the disease (5.4 vs. 4.8 g/l, p>0.05). Death was associated with increased platelet to lymphcyte ratio (370 vs. 271, p=0.003) and low prothrombin ratio (52% vs. 66%, p=0.001). Lymphopenia (Lymphocytes Conclusion: Hematological changes could be an indicator of the severity and the prognosis of COVID-19. |
