Acebutolol in Mild to Moderate Hypertension

Autor:	Judith A. Whitworth, A. S. P. Hua, Priscilla Kincaid-Smith, S. Kalowski
Rok vydání:	1980
Předmět:	medicine.medical_specialty Supine position business.industry Thiazide diuretic General Medicine Placebo Crossover study Acebutolol Double blind Blood pressure Internal medicine medicine Cardiology business Chlorothiazide medicine.drug
Zdroj:	Medical Journal of Australia. 1:226-228
ISSN:	1326-5377 0025-729X
DOI:	10.5694/j.1326-5377.1980.tb134777.x
Popis:	The effect of acebutolol (Sectral) was compared with that of placebo in 30 patients with mild to moderate hypertension who were receiving a thiazide diuretic. Ten patients did not complete the study. In the remaining 20 patients, acebutolol (mean dose, 910 +/- 408 mg/day) produced significantly greater reduction both in supine and in erect systolic and diastolic blood pressure over 16 weeks than placebo plus chlorothiazide P less than 0.005). Pulse rate also fell significantly. Four patients did not have a consistent reduction in blood pressure. Acebutolol was found to be an effective hypotensive agent with relatively few side effects.
Databáze:	OpenAIRE
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