Homocysteine metabolism, growth performance, and immune responses in suckling and weanling piglets1
| Autor: | Frédéric Beaudoin, J. J. Matte, L. Lo Verso, Christiane L. Girard, Martin Lessard, I. Audet |
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| Rok vydání: | 2015 |
| Předmět: |
Litter (animal)
Vitamin medicine.medical_specialty integumentary system Homocysteine animal diseases Weanling General Medicine Biology bacterial infections and mycoses chemistry.chemical_compound fluids and secretions Endocrinology medicine.anatomical_structure Blood serum chemistry Internal medicine Lactation Blood plasma Genetics medicine Weaning Animal Science and Zoology Food Science |
| Zdroj: | Journal of Animal Science. 93:147-157 |
| ISSN: | 1525-3163 0021-8812 |
| DOI: | 10.2527/jas.2014-7872 |
| Popis: | Homocysteine (Hcy), an intermediary sulfur AA, is recognized as a powerful prooxidant with deleterious effects on physiological and immune functions. In piglets, there is an acute 10-fold increase of plasma concentrations of homocysteine (pHcy) during the first 2 wk of life. This project aimed to maximize pHcy variations within physiological ranges using typical supplies of folates and vitamin B12 (B12) to sows and piglets. Growth, immune response, and Hcy metabolism of piglets were studied until piglets reached 56 d of age. Third-parity sows were randomly assigned to a 2 × 2 split-plot design with 2 dietary treatments during gestation and lactation, S(-) (1 mg/kg folates and 20 µg/kg B12, n = 15) and S(+) (10-fold S(-) levels, n = 16), and 2 treatments to piglets within each half litter, intramuscular injections (150 µg) of B12 (P(+)) at d 1 and 21 (weaning) and saline (P(-)). Within each litter of 12 piglets, 3 P(+) and 3 P(-) piglets were studied for growth and Hcy metabolism, and the others were studied for immune responses. During lactation, plasma B12 decreased and was transiently greater in S(+) vs. S(-) piglets on d 1 and P(+) vs. P(-) piglets on d 7 (sow treatment × age and piglet treatment × age; P 0.29, P 21 µM) compared to medium (17 to 21 µM) or low ( |
| Databáze: | OpenAIRE |
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