Double dissociation of deficits in visuospatial memory and executive function in patients with major depression with and without ECT referral
| Autor: | D. Kontis, Eirini Theochari, Stamatina Kalogerakou, Cornelia Poulopoulou, Eleftheria Tsaltas, V.-M. Papakosta, P. Oulis, E. Anyfandi, Ioannis Michopoulos, M. Koutroumpi |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_treatment
Cambridge Neuropsychological Test Automated Battery Neuropsychology Cognition Neuropathology medicine.disease behavioral disciplines and activities Spatial memory Psychiatry and Mental health Electroconvulsive therapy mental disorders medicine Major depressive disorder Psychology Depression (differential diagnoses) Clinical psychology |
| Zdroj: | European Psychiatry. 26:1146-1146 |
| ISSN: | 1778-3585 0924-9338 |
| DOI: | 10.1016/s0924-9338(11)72851-6 |
| Popis: | IntroductionThe pretreatment neuropsychological profile of drug-resistant patients with major depressive disorder (MDD) referred for electroconvulsive therapy (ECT) may differ from that of their drug-respondent MDD counterparts. Such differences could help in identifying distinct MDD subtypes, thus offering insights into the neuropathology underlying differential treatment responses.MethodDepressed patients with ECT referral (ECTs), depressed patients with no ECT referral (NECTs) and nonpsychiatric Controls (matched groups, n = 15) were assessed with memory and executive function tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB).ResultsECTs scored significantly lower than NECTs in the Mini-Mental State Examination (MMSE; p = 0.01). NECTs performed worse than Controls in the Paired Associates Learning (PAL) task (p < 0.03 ; Control/NECT p < 0.01) and the Spatial Recognition Memory (SRM) task (p < 0.05 ; Controls/NECTs p < 0.05) ; ECTs performed between Controls and NECTs, not differing from either. In the Intra/Extradimensional (IED) set-shifting task, ECTs performed worse that Controls and NECTS (IED: p < 0.01 ; Controls/ECTs p < 0.01), particularly in the shift phases, which suggests reduced attentional flexibility. In Stockings of Cambridge (SOC), ECTs abandoned the test early more often than Controls and NECTs (H = 11, p < 0.01) but ECTs who completed SOC performed comparably to the other two groups.ConclusionsA double dissociation emerged from the comparison of cognitive profiles of ECT and NECT patients. ECTs showed executive deficits, particularly in attentional flexibility, but mild deficits in tests of visuospatial memory. NECTs presented the opposite pattern. This suggests predominantly frontostriatal involvement in ECT versus temporal involvement in NECT dépressives. |
| Databáze: | OpenAIRE |
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