Hole transport in DNA hairpins via base mismatches and strand crossings: Efficiency and dynamics

Autor: Frederick D. Lewis, Michael R. Wasielewski, Arun K. Thazhathveetil, Ryan M. Young, Michelle A. Harris
Rok vydání: 2016
Předmět:
Zdroj: Journal of Photochemistry and Photobiology A: Chemistry. 331:160-164
ISSN: 1010-6030
DOI: 10.1016/j.jphotochem.2016.03.002
Popis: The efficiency and dynamics of hole transport via base mismatches and strand crossings have been determined for 10 DNA hairpins by means of femtosecond transient absorption spectroscopy. The hairpins possess a stilbenedicarboxamide hole donor and stilbenediether hole acceptor separated by seven base pairs. Hole transport occurs via an intra- or interstrand A 3 G 4 diblock purine sequence that contains either a single base pair mismatch or strand crossing. Pyrimidine-pyrimidine mismatches (TT or CC) effectively block intrastrand hole transport; whereas purine-purine mismatches (AA or GG) permit efficient interstrand hole transport. Purine-to-purine intrastrand hole transport between adjacent matched base pairs is also moderately efficient (AG > AA > GG). Based upon these results AA mismatches are being employed in the design of three-way junctions for incorporation in prototype charge splitting and charge combining devices.
Databáze: OpenAIRE