| Autor: |
Samuel A. Giday, Mohamed Hassan, Tammy Naab, Alpha Banks, Mamoon Elbedawi, Syed Hasan, Oswaldo Castro, Duane T. Smoot |
| Rok vydání: |
2003 |
| Předmět: |
|
| Zdroj: |
Gastroenterology. 124:A752 |
| ISSN: |
0016-5085 |
| DOI: |
10.1016/s0016-5085(03)83797-6 |
| Popis: |
Objective: To evaluate the effects of HCV mfectinn on hepatic pathology m sickle cell patients with Iron overload. Patients and Methods: Between 1992 and 2002, twenty of 44 sickle cell patients with territni level more than 1000 ng/dl agreed to have hver biopsy at Howard University Hospital (50% men, 50% women, median age 37 years). All the patients had multiple transfusmns in the past (more than 40 units) The majority of the patients (90%) had Hemoglobin SS and 10% had Hemoglobin SC. None of the patients had iron chelation therapy prior to biopsy. Liver biopsy results and clinical reem'ds were retrospectively reviewed. A blinded pathologist performed the histopathologic assessments of liver biopsies. Histology including hepatic iron content was graded. Results: Hemosidemsis was present in all of the biopsy' specimens. Fourteen (70%) had 4 + iron depositions in bepatocyles, one patient had 3 + , one patient had 2 + and three patients had only 1 + hepatic iron deposition. One patient had pigment granules in hepatocytes but no iron stain was performed. Advanced cirrhosis was noted in three patients, recipient cirrhosis in one patient and bridging fibrosis in three patients Patchy sinusoidal fibrosis was obser`,'ed in eight patients. All the patients with advanced and incipient cirrhoses had anti HCV antibodies, whereas only two patients with patchy sinusoidal fibrosis were HCV positive. Only one patient with HCV infection had no evidence of fibrosis All patients with HCV refection had 4 + hepatic iron whereas only 61% of patmnts without HCV refection had 4 + -iron deposition, considering that all received simi 'lar number of transfusions. Conclusion: Our data indicates that patients with sickle cell disease who have hepatitis C virus infection are at an increased risk of developing severe hepatic iron overload and advanced cirrhosis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
