The role of preproglucagon peptides in regulating β-cell morphology and responses to streptozotocin-induced diabetes

Autor:	Deanna M. Arble, Chelsea R. Hutch, Hannah Hafner, Daria Stelmak, Kyle Leix, Joyce Sorrell, Joshua W. Pressler, Brigid Gregg, Darleen A. Sandoval
Rok vydání:	2023
Předmět:	Physiology Physiology (medical) Endocrinology Diabetes and Metabolism
Zdroj:	American Journal of Physiology-Endocrinology and Metabolism. 324:E217-E225
ISSN:	1522-1555 0193-1849
DOI:	10.1152/ajpendo.00152.2022
Popis:	We examined the role of Gcg on β-cell function under normal and high glucose conditions. GcgNull mice had decreased glucose-stimulated insulin secretion, increased β-cell mass, and partial protection against STZ-induced hyperglycemia. Expression of Gcg within the pancreas normalized these endpoints. Intestinal expression of Gcg only normalized β-cell mass and glucose-stimulated insulin secretion. Increased β-cell mass in GcgNull mice likely compensated for decreased insulin secretion normalizing physiological glucose levels and conferring some protection after STZ-induced diabetes
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::48d586cf4688304fd5c085fff5054b6a https://doi.org/10.1152/ajpendo.00152.2022 Zobrazit plný text záznamu