Selective Class III Antiarrhythmic Properties of a Novel Agent, UK-66,914, During Chronic Myocardial Infarction
| Autor: | John R. Onufer, Harris W. Dalrymple, Peter B. Corr |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Inotrope
medicine.medical_specialty business.industry Effective refractory period Hemodynamics medicine.disease Ventricular tachycardia Procainamide Nerve conduction velocity Physiology (medical) Internal medicine medicine Cardiology Myocardial infarction Cardiology and Cardiovascular Medicine business Ionotropic effect medicine.drug |
| Zdroj: | Journal of Cardiovascular Electrophysiology. 2:117-133 |
| ISSN: | 1540-8167 1045-3873 |
| DOI: | 10.1111/j.1540-8167.1991.tb01311.x |
| Popis: | Antiarrhythmic Properties of UK- 66,914. UK-66,914 is a potent Class III antiarrhythmic agent that has no effect on conduction velocity in normal tissue in vitro. The present study was performed to evaluate the influence of UK-66,914 on conduction velocity in vivo in canine hearts with a previous myocardial infarction. Detailed three-dimensional mapping of the heart in vivo was obtained using simultaneous recordings from 232 transmural sites. In dogs with a chronic anterior myocardial infarction, UK-66,914 (50 μg/kg) did not alter conduction velocity in regions exhibiting normal conduction (gt; 50 cm/sec) or regions with slowed conduction ( 30 cm/sec, 15-30 cm/sec, or < 15 cm/sec, whereas procainamide significantly decreased conduction velocity at all three levels. Evaluation of the hemodynamic profile of UK-66,914 revealed no negative ionotropic effects in conscious dogs even at doses twentyfold those required to elicit increases in the effective refractory period. Therefore, UK-66,914 is a potent and specific Class III antiarrhythmic agent, which does not alter conduction velocity in hearts with a previous myocardial infarction and exerts no negative inotropic effects. |
| Databáze: | OpenAIRE |
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