The effect of food on the gastrointestinal transit and systemic absorption of naproxen from a novel sustained release formulation

Autor:	G. Hooper, John Devane, D. Tierney, C. J. Kenyon, J. Butler, Ian R. Wilding
Rok vydání:	1995
Předmět:	Naproxen Gastric emptying business.industry Stomach digestive oral and skin physiology Pharmaceutical Science Pharmacology Dosage form Small intestine Bioavailability medicine.anatomical_structure Pharmacokinetics Oral administration medicine business medicine.drug
Zdroj:	Journal of Controlled Release. 34:31-36
ISSN:	0168-3659
DOI:	10.1016/0168-3659(94)00118-e
Popis:	The in vivo behaviour of a novel sustained release formulation of naproxen was investigated using gamma scintigraphy in eight healthy male volunteers under fasted and fed conditions. Disintegration of the tablet into discrete sustained release pellets occurred in the stomach shortly after administration. Feeding resulted in a lag time prior to the onset of gastric emptying but food did not affect transit through the small intestine. Post-prandial administration of the sustained release formulation did not affect the disintegration of the tablet or the bioavailability of the drug.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::48c9ad854b1091630891799dd2b30c0d https://doi.org/10.1016/0168-3659(94)00118-e Zobrazit plný text záznamu Full Text from ScienceDirect