Femoral Cartilage Thickness and Vitamin D Level in Systemic Sclerosis Patients and Relation to Disease Severity
| Autor: | Hanan Mohamed Farouk, Fatma Mohammed Badr, Safaa A. Hussein, Mohammed Abd El Monem Teama |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
030203 arthritis & rheumatology
medicine.medical_specialty medicine.diagnostic_test business.industry Physical examination Musculoskeletal ultrasound Intercondylar area medicine.disease Femoral cartilage Gastroenterology Scleroderma 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Disease severity Internal medicine medicine Vitamin D and neurology Medical history business |
| Zdroj: | The Egyptian Journal of Hospital Medicine. 81:1977-1984 |
| ISSN: | 2090-7125 |
| DOI: | 10.21608/ejhm.2020.123483 |
| Popis: | Background: Systemic sclerosis (SSc) is a heterogeneous autoimmune disorder associated with vascular dysfunction and fibrotic changes. Low vitamin D levels and decreased femoral cartilage thickness (FCT) have been observed in SSc. Objectives: This study aimed to evaluate the relation between serum level of vitamin D and FCT among SSc patients and to correlate both with clinical features and disease severity score. Patients and Methods: This study included 40 SSc patients, divided into 2 groups; group 1: sufficient vitamin D (level > 30 ng/ml), group 2: insufficient vitamin D (level < 30 ng/ml). All patients were subjected to history taking, clinical examination, and assessment of disease severity by Medsger Disease Severity Index (MDSI), laboratory investigations, 25 (OH) vitamin D level and musculoskeletal ultrasound of both knees to assess FCT. Three midpoint measurements of FCT were taken from each knee: lateral femoral condyle (LFC), femoral intercondylar area (ICA) and medial femoral condyle (MFC). Results: Thin FCT was found in 60% of patients. There was insufficient vitamin D level in 65% of patients. Age was negatively correlated with FCT at right MFC area and female parity was also negatively correlated with right ICA and MFC areas. FCT was significantly lower in group 1 at areas of left MFC and LFC areas, but no relation between femoral cartilage thickness and vitamin D level with disease severity. Conclusion: There is significant relation between femoral cartilage thickness and vitamin D level in scleroderma patients, both decline in SSc patients but not related to disease severity score. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|