Synthesis, anti-inflammatory activity, and QSAR study of some Schiff bases derived from 5-mercapto-3-(4′-pyridyl)-4H-1,2,4-triazol-4-yl-thiosemicarbazide
| Autor: | Rekha Saroj, Sarita Khaturia, Kapil Arya, Harshita Sachdeva, Diksha Dwivedi |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Quantitative structure–activity relationship
medicine.drug_class Organic Chemistry Hydrazine Carbon-13 NMR Microwave method Medicinal chemistry Anti-inflammatory chemistry.chemical_compound chemistry Microwave irradiation medicine Proton NMR Organic chemistry General Pharmacology Toxicology and Pharmaceutics Paw edema |
| Zdroj: | Medicinal Chemistry Research. 22:4953-4963 |
| ISSN: | 1554-8120 1054-2523 |
| Popis: | The purpose of this research is to synthesize better anti-inflammatory compounds derived from 5-mercapto-3-(4′-pyridyl)-4H-1,2,4-triazol-4-yl-thiosemicarbazide (5). 2-Substituted-N-[3-(pyridin-4-yl)-5-sulfanyl-4H-1,2,4-triazol-4-yl]hydrazine carbothioamide derivatives (6a–j)/(7a–e) are synthesized by the condensation of 5 with variously substituted aromatic aldehydes/1H-indole-2,3-diones, respectively, under conventional and microwave irradiation methods. The microwave method is found to be superior with higher chemical yields, tremendous reduction in time, and is environmentally benign as compared to conventional heating method. The chemical structures of the newly synthesized compounds (6/7) have been confirmed by IR, 1H NMR, and 13C NMR spectra and have been evaluated for anti-inflammatory activity by carrageenan-induced acute paw edema method in rats. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink