Effects of Ascorbic Acid Intake on the Intima-Media Thickness and Blood Flow Velocities of the Carotid Artery in Patients With Sickle Cell Anemia
| Autor: | Ololade M. Adekunle, Adekunle Adeyomoye, Gbolahan O. Awosanya, Omodele A. Olowoyeye, S I Jaja, Omobolanle O. Tubi, NK Irurhe, RA Arogundade, Kofoworola O. Soyebi, Michael O. Kehinde, Busola K. Soneye |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Radiological and Ultrasound Technology Vitamin C Anemia business.industry Carotid arteries Blood flow medicine.disease Sickle cell anemia Intima-media thickness Internal medicine medicine.artery medicine Cardiology Radiology Nuclear Medicine and imaging In patient Common carotid artery business |
| Zdroj: | Journal of Diagnostic Medical Sonography. 27:214-219 |
| ISSN: | 1552-5430 8756-4793 |
| Popis: | This study aims to investigate and compare the effects of six-week oral vitamin C supplementation on blood velocities, intima-media thickness, and cross-sectional diameter (CSD) of the common carotid artery of sickle cell anemia (SCA) and non–sickle cell anemia (NSCA) subjects using sonography. Results showed that the CSD and end-diastolic velocity were significantly higher ( P < .002 and P < .001, respectively) in the SCA subjects than in the NSCA subjects in the presupplementation phase. Calculated resistivity index (RI) was significantly lower in the SCA subjects ( P < .003). Vitamin C supplementation had a slight effect on all the measured parameters in the NSCA subjects but caused a significant increase in peak systolic velocity (PSV) ( P < .02) and RI ( P < .01) in SCA. A comparison of change in each measured variable between the groups showed significant differences. Oral supplementation with vitamin C should be encouraged in patients with SCA as prophylaxis against endothelial damage, thereby preventing vaso-occlusive crises and their associated morbidity. |
| Databáze: | OpenAIRE |
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