High-performance liquid chromatographic and capillary electrophoretic methods for the quantitation of the (S)-terbutaline in (R)-terbutaline
| Autor: | Hyung-Giun Kim, JongPill Lee, Kyong-Ha Kim, Juyeol Kim, S. C. Lee |
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| Rok vydání: | 2001 |
| Předmět: |
Detection limit
Chromatography Capillary action Chemistry Organic Chemistry Clinical Biochemistry Terbutaline Analytical chemistry Biochemistry High-performance liquid chromatography Analytical Chemistry Capillary electrophoresis polycyclic compounds medicine Enantiomer Enantiomeric excess Quantitative analysis (chemistry) medicine.drug |
| Zdroj: | Chromatographia. 53:334-337 |
| ISSN: | 1612-1112 0009-5893 |
| DOI: | 10.1007/bf02490436 |
| Popis: | The resolution of chiral drugs, metabolites and related substances continues to be an important area in pharmaceutical analysis. Two methods for the optical purity testing of (R)-(-)-terbutaline were developed, namely capillary electrophoresis using hydroxypropyl-β-cyclodextrin and high-performance liquid chromatography using a chiral stationary phase. Validation data such as linearity, recovery, detection limit, and precision of the two methods are presented. The detection limit of (S)-terbutaline in (R)-terbutaline was 0.05% by the HPLC method and 0.03% by the CE method. The was generally good agreement between the HPLC and CE results. These methods were found to be applicable as a practical quality control method for the enantiomeric purity determination of(R)-terbutaline. |
| Databáze: | OpenAIRE |
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