Plant 'helper' immune receptors are Ca 2+ -permeable nonselective cation channels

Autor:	Pierre Jacob, Li Wan, Korina Kempthorn, William G. Walton, Zhen-Ming Pei, Matthew R. Redinbo, Adam D. Lietzan, Nak Hyun Kim, Farid El-Kasmi, Jeffery L. Dangl, Fei-Hua Wu, Oliver J. Furzer, Yuan Chi, Sruthi Sunil
Rok vydání:	2021
Předmět:	Programmed cell death Multidisciplinary Immune system biology Chemistry Cytoplasm Arabidopsis HEK 293 cells Patch clamp biology.organism_classification Receptor Calcium signaling Cell biology
Zdroj:	Science. 373:420-425
ISSN:	1095-9203 0036-8075
DOI:	10.1126/science.abg7917
Popis:	Calcium signaling for host cell death In response to microbial pathogens, some plants kill off their own cells to limit further spread of infection. The Toll/Interleukin-1 receptor/Resistance class of nucleotide-binding leucine-rich repeat receptors (known as TNLs) function in plants as immune receptors. These TNLs work together with a dedicated set of helper proteins. Jacob et al. reveal the structure of one of these helpers known as NRG1 (N REQUIREMENT GENE 1). The structure resembles a known animal cation channel. The authors demonstrate that helper NLRs directly control calcium ion influx to initiate host cell death, providing a mechanism for TNL outputs. Science , abg7917, this issue p. 420
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::489dd133253b1fe68ae529993c384d1c https://doi.org/10.1126/science.abg7917 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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