Setting simultaneous specifications on multiple raw materials to ensure product quality and minimize risk
| Autor: | John F. MacGregor, Mark-John Bruwer, Zheng Liu, Boris Polsky, Glenn Visscher |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0209 industrial biotechnology
Multivariate statistics Computer science Process Chemistry and Technology media_common.quotation_subject Control (management) 02 engineering and technology Raw material 030226 pharmacology & pharmacy Poor quality Computer Science Applications Analytical Chemistry Reliability engineering Product (business) Ensure (product) 03 medical and health sciences 020901 industrial engineering & automation 0302 clinical medicine Quality (business) Multivariate statistical Spectroscopy Software media_common |
| Zdroj: | Chemometrics and Intelligent Laboratory Systems. 157:96-103 |
| ISSN: | 0169-7439 |
| DOI: | 10.1016/j.chemolab.2016.06.021 |
| Popis: | Establishing meaningful multivariate specification regions on the multiple properties of a single raw material has been presented and illustrated by Duchesne & MacGregor Duchesne and MacGregor (2004) . However, the manufacture of most final products usually involves the use of many raw materials each with multiple measured properties and from different suppliers. Setting specifications separately on each of these materials is unreasonable since it is the simultaneous combination of the properties of all the materials that will affect final quality. This paper presents an approach to determining the acceptability of new lots of raw materials from multiple suppliers and of assessing the suitability of combining specific lots of materials currently in inventory that will minimize the risk of manufacturing a poor quality product. Multivariate statistical models based on PLS are used to determine the importance of all the properties of each of the materials and to develop the specification methodology. Use of the models for achieving improved control over the product quality is also discussed. |
| Databáze: | OpenAIRE |
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