| Autor: |
Dai Song Wang, Kai Yue, Lin Chen, Bao Miao Ma, Chao Ying Li, Yong Qing Gan, Xiao Kang Gong, Jun Qiao Xing, Qin Ru, Lu Liu, Qi Xiong, Guo Zhang Jin, Xiang Tian |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Advanced Materials Research. :169-172 |
| ISSN: |
1662-8985 |
| DOI: |
10.4028/www.scientific.net/amr.998-999.169 |
| Popis: |
Given the problems associated with the escalation in methamphetamine (METH) use, the identification of more effective treatment strategies is essential. l-stepholidine (l-SPD) is an alkaloid extract of the Chinese herb Stephania intermedia with dopamine D1 receptor partial agonistic and D2 receptor antagonistic dual actions. The unique pharmacological profile of l-SPD suggests that l-SPD may be effective for the treatment of METH addiction. The aim of this study was to characterize the effect of l-SPD on METH self-administration on a fixed-ratio 1 schedule. We found that 5 and 10 mg/kg of l-SPD attenuated METH self-administration behavior. These results demonstrate that l-SPD which possesses dual actions on dopamine D1 and D2 receptors, attenuates METH self-administration on a fixed-ratio 1 schedule. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
