Synthesis and Neuropsychotropic Activity of Indole-Containing Gamma-Aminobutyric Acid Derivatives
| Autor: | O. V. Merkushenkova, V. M. Berestovitskaya, S. M. Aleksandrova, E. S. Ostroglyadov, O. S. Vasil’eva, Ivan N. Tyurenkov, V. V. Bagmetova |
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| Rok vydání: | 2018 |
| Předmět: |
Pharmacology
Indole test 010405 organic chemistry Chemistry Stereochemistry medicine.drug_class Pharmacology toxicology Alkaline hydrolysis (body disposal) 010402 general chemistry 01 natural sciences Anxiolytic gamma-Aminobutyric acid 0104 chemical sciences Nootropic 13c nmr spectroscopy Drug Discovery medicine Molecule medicine.drug |
| Zdroj: | Pharmaceutical Chemistry Journal. 52:392-396 |
| ISSN: | 1573-9031 0091-150X |
| Popis: | A series of indole-containing γ-aminobutyric acids (GABA) were synthesized via alkaline hydrolysis of 4-(indol-3-yl)-2-pyrrolidones. Their structures were confirmed by IR, PMR, and 13C NMR spectroscopy. Studies of the pharmacological properties of 4-amino-3-indolylbutanoic acids (GABA derivatives) showed that they possessed neuropsychotropic activity, the spectrum of which depended on the acid molecular structure. Nootropic properties prevailed for 4-amino-3-(indol-3-yl)butanoic acid; anxiolytic activity, for 4-amino-3-(1-benzylindol-3-yl)butanoic acid. |
| Databáze: | OpenAIRE |
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