Sleep Abnormalities and Sleep Breathing Disorders in Children with Drug- Resistant Catastrophic Epileptic Encephalopathy
Autor: | Anna Annunziata, Anna Michela Gaeta, Francesca Gaeta, Giuseppe Fiorentino, Gianfranco Scotto di Frega |
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Rok vydání: | 2015 |
Předmět: |
medicine.medical_specialty
Pediatrics medicine.diagnostic_test business.industry Drug resistance Polysomnography medicine.disease Sleep in non-human animals Comorbidity nervous system diseases respiratory tract diseases Surgery Cerebral palsy Epilepsy stomatognathic system Quality of life Medicine business Hypopnea |
Zdroj: | Journal of Sleep Disorders & Therapy. |
ISSN: | 2167-0277 |
Popis: | Undiagnosed obstructive sleep apnoea is common in patients with medically refractory epilepsy. The aim of this study is to evaluate sleep alterations and the prevalence of Sleep Breathing Disorders (SBD) in a paediatric population with catastrophic epileptic encephalopathy. To diagnose SBD, polysomnography (PSG) was performed in eleven patients (nine males, two females), with ages ranging between 3 and 11 years old, with epileptic encephalopathy characterized by drug-resistant seizures, occurring both in sleeping and waking, mental retardation and cerebral palsy. All the patients presented alterations of the sleep architecture and were positive for SBD. In particular, seven patients presented a severe form of Obstructive Sleep Apnoea Syndrome (OSAS) with apnoea/ hypopnea index (AHI) greater than10/hr, two patients presented a moderate form with AHI between 5/hr and 10/hr, two patients presented a mild form with AHI lower than 4/hr. In conclusion, SBD and sleep disruption appeared to be in comorbidity with catastrophic epileptic encephalopathy. Their treatment might also have a positive impact in seizures control and quality of life. |
Databáze: | OpenAIRE |
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