Treatment of Advanced Localised Prostatic Cancer by Orchiectomy, Radiotherapy, or Combined Treatment. A Medical Research Council Study

Autor:	Richard Peto, C. Keen, G. J. Fellows, J.N. Webb, P. B. Clark, M. C. Parkinson, L. L. Beynon, J Boreham
Rok vydání:	1992
Předmět:	medicine.medical_specialty Epithelioma business.industry Urology medicine.medical_treatment Cancer medicine.disease law.invention Surgery Radiation therapy medicine.anatomical_structure Randomized controlled trial law Prostate Medicine Combined Modality Therapy Prostate surgery Orchiectomy business
Zdroj:	British Journal of Urology. 70:304-309
ISSN:	1464-410X 0007-1331
DOI:	10.1111/j.1464-410x.1992.tb15736.x
Popis:	A total of 277 patients with apparently localised prostatic cancer (T2-T4 NXMO) were allocated at random to receive radiotherapy alone (88), orchiectomy alone (90) and combined therapy (99) between 1980 and 1985. The main outcome measures were survival, time to appearance of metastases and treatment of local disease progression by further transurethral resection. Orchiectomy, whether alone or with radiotherapy, produced a significant delay in detection of metastases when compared with radiotherapy alone. There were no statistically significant differences between the 3 treatment groups in local disease control or in overall survival.
Databáze:	OpenAIRE
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