Influence of i KCNJ11 i gene polymorphism in T2DM of south Indian population
| Autor: | Dhasaiya Viji, Rehman Syed Rasheed Akram Husain, Sahul Hameed Noorul Ameen, Prathap Seelan Pricilla Charmine, Shiek S. S. J. Ahmed, Rajagopalan P. Aswathi, V. Ramakrishnan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
endocrine system diseases
General Immunology and Microbiology nutritional and metabolic diseases Odds ratio Biology medicine.disease General Biochemistry Genetics and Molecular Biology Confidence interval Polymorphism (computer science) Diabetes mellitus Genetic model Genotype medicine Gene polymorphism Allele Demography |
| Zdroj: | Frontiers in Bioscience. 12:199-222 |
| ISSN: | 1945-0508 1945-0494 |
| Popis: | Type-2 Diabetes mellitus (T2DM) is a complex metabolic disease. A case-control study was conducted with 218 T2DM and 214 controls to evaluate the T2DM risk of rs5219 polymorphism in the south Indian population. The analysis of allelic and genotype data showed a significant association of rs5219 polymorphism towards an increased risk of T2DM compared to controls with an odds ratio (OR) of 2.52, confidence interval (CI) (0.96-6.64) and p-value 0.046. The functional influence of rs5219 was tested which showed a significant correlation with HbA1c and serum uric acid levels. Although our results confirm rs5219 is a potential contributor to T2DM, several inconclusive results were noticed across the literature. Hence, the meta-analysis was performed by combining the results of case-control study with previous literature to confirm the rs5219 association with T2DM across various populations. Our meta-analysis revealed a significant risk association of rs5219 in T2DM under five genetic models. In summary, our analysis suggests, rs5219 polymorphism plays a significant role in T2DM susceptibility. Further, studies need to be conducted to determine the influence of rs5219 on the other characteristics of T2DM. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|